Histamine Intolerance (HI)

Histamine intolerance is a systemic disorder from buildup of excessive histamine resulting from lower than normal levels of enzymes that metabolize (break down) histamine and/or excessive release of histamine.

How Histamine Is Regulated

Normally, histamine is rapidly metabolized, or broken down, by diamine oxidase (DAO). This enzyme breaks down the histamine found in many foods and scavenges extracellular histamine released into the system by mast cells – a type of white bood cell. Another enzyme, histamine N-methyltransferase (HNMT), breaks down the histamine inside the cells of your body. Exposure to sulfites and phenolic compounds tends to increase histamine levels.

How Histamine Intolerance Occurs

Excessively high histamine results in a wide array of symptoms and can mimic or contribute to other health problems. Histamine intolerance is often overlooked and not addressed leaving people with chronic symptoms and no answers.

Mast Cell Activation Syndrome (MCAS)

A subset of Histamine Intolerance is Mast Cell Activation Syndrome where the mast cells containing histamine release abnormally large amounts of histamine into the rest of the body.

Managing Histamine Effects

Avoiding foods that are high in histamine and taking antihistamine drugs (Claritin, Allergra, Zrytec) to block histamine receptors can be a useful. Neither method solves the issues of excessive release and inadequate breakdown of histamine.

Histamine Intolerance Symptoms

Many of the symptoms mimic allergic reaction. Other symptoms can include  headache, eye and sinus symptoms, irregular or rapid heart rate, rash, itching, flushing, gastrointestinal (nausea, vomiting, diarrhea, abdominal pain, bloating, malabsorption), low blood pressure, dizziness or fainting, muscle, joint, and bone pain, fatigue, anxiety, and impaired focus and memory (foggy-headedness).

Symptoms of Histamine Intolerance


Many of the symptoms mimic allergic reaction. Other symptoms can include headache, eye and sinus symptoms, irregular or rapid heart rate, rash, itching, flushing, gastrointestinal problems, low blood pressure, dizziness or fainting, fatigue, anxiety, and more.

How can I tell if I have Histamine Intolerance


People with Histamine Intolerance are very likely to show dermatographia – also known as skin writing. If you find that scratching your skin results in the scratches reddening into a raised weal similar to hives it is very likely you have Histamine Intolerance.

Dermatographia: A Simple Self Test For HI

People with Histamine Intolerance are very likely to show dermatographia – also known as skin writing. If you find that scratching your skin results in the scratches reddening into a raised weal similar to hives it is very likely you have Histamine Intolerance. The marks usually disappear within around 30 minutes. This is just a screening test – it’s not definitive. You should investigate the possibility that you have HI if you show dermatographia.

A Physician Can Diagnose HI/MCAS

Both Histamine Intolerance and Mast Cell Activation Syndrome have distinct diagnostic criteria. A physician familiar with these disorders will be able to do the history and exams and order lab tests to find out if you have HI/MCAS.

How Vinami Can Help

Vinami was originally designed to help people with wine intolerance be able to drink wine. Histamine is one of the compounds that cause people to react to wine and developing a formula that supports metabolism of histamine and regulation of mast cell histamine release was necessary for the formula to work.

Vinami contains nutrients essential for production of diamine oxidase (DAO) and histamine N-methyltransferase (HNMT) and regulation of histamine from mast cells. Vinami also supports the metabolism of sulfites and phenolic compounds, two families of compounds that contribute to excessively high histamine levels.

Using Vinami

Consider a 6—8 week trial of using Vinami to see how effective it is in helping you control histamine levels and improve histamine tolerance.

There is a genetic predisposition to histamine intolerance. Vinami does not and cannot cure the predisposition to histamine intolerance. If you find using Vinami helps alleviate your symptoms, continue taking Vinami on a maintenance basis.

Solving Histamine Intolerance


Learn how chemical intolerance and histamine intolerance are related to one another. Gain clarity about what steps you need to take to free yourself with our six part email program.